Acetaminophen is so toxic to the liver that it has become the leading cause of acute liver failure (Hepatology 2005; 42:1364-72). Even short-term use of acetaminophen taken at the maximum recommended daily dose stresses the liver (JAMA 2006; 296:87-93). The study also concluded that acetaminophen dulls your emotions. (Psychological Science 2015; 26:750-8).