The American Chiropractor/ November 2025 Issue

NSAIDs Side Effects and Safe Nutritional Support

Most know Intuitively know that non-steroidal anti- inflammatory drugs (NSAIDs) such as aspirin and ibuprofen are counterproductive for bone and tissue healing when taken long term, but are you aware that they work against you from the beginning, even if they are taken on a short-term basis? 


It is well established that taking NSAIDs long term is detrimental to the kidneys, circulatory system, gut, and structure of bone, connective tissue, and muscle. For instance, NSAIDs interfere with the prostaglandin pathway.  There are beneficial prostaglandins that make up the mucus lining of our stomach and intestines. continued use wears away the protective lining and results in ulcer formation.  Certain processes are necessary for tissue regeneration. NSAIDs can inhibit repair pathways. One example is a neutrophil process that causes inflammation while helping resolve it, but it is blocked by NSAIDs. another example is resolvins that are made as by-products from fish oil. Resolvins help resolve pain and inflammation, but NSAIDs interfere with the production of resolvins and the resolution of pain and inflammation.

Most know Intuitively know that non-steroidal anti- inflammatory drugs (NSAIDs) such as aspirin and ibuprofen are counterproductive for bone and tissue healing when taken long term, but are you aware that they work against you from the beginning, even if they are taken on a short-term basis? 


It is well established that taking NSAIDs long term is detrimental to the kidneys, circulatory system, gut, and structure of bone, connective tissue, and muscle. For instance, NSAIDs interfere with the prostaglandin pathway.  There are beneficial prostaglandins that make up the mucus lining of our stomach and intestines. continued use wears away the protective lining and results in ulcer formation.  Certain processes are necessary for tissue regeneration. NSAIDs can inhibit repair pathways. One example is a neutrophil process that causes inflammation while helping resolve it, but it is blocked by NSAIDs. another example is resolvins that are made as by-products from fish oil. Resolvins help resolve pain and inflammation, but NSAIDs interfere with the production of resolvins and the resolution of pain and inflammation.

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